WWE SmackDown - Season 12 Episode 43 October 22, 2010 (Edmonton, Alberta, Canada)
Tonight's episode of SmackDown is being broadcast from the Rexall Place in Edmonton, Alberta, Canada. The scheduled matches for tonight's card are: Six Man Tag Team Match - Kofi Kingston, Rey Mysterio & The Big Show vs. Ezekiel Jackson, Sheamus & The Miz Singles Match - Jack Swagger vs. Santino Marella Singles Match - Alberto Del Rio vs. John Morrison Singles Match - CM Punk vs. Edge Tag Team Match - LayCool (Layla & Michelle McCool) vs. Kelly Kelly & Natalya Non Title Match - Kane vs. Randy Orton
- Genre: Reality
- Studio: FOX, USA Network, UPN, The CW, Syfy, MyNetworkTV
- Keyword: wrestling, sports entertainment
- Cast:
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